【Suzhou】CAR-T Cell Immunotherapy for Novel Anticancer Treatment

CAR-T cell immunotherapy is a new type of targeted therapy for tumor treatment, the basic principle of which is to load in vitro activated T-cells with CAR, which recognizes specific tumor antigens. Through genetic engineering technology, they are infused into patients. The modified T-cells can recognize tumor cells in vivo through the CAR molecule on their surface and kill tumor cells so as to treat malignant tumors.

The program invites experts to learn about the preparation and application of CAR-T cells and provide necessary theoretical and practical support for a deep understanding of T cell-based immunotherapy.

XLAB taught me about various branches of biology, such as molecular biology and biotechnology. For example, the PCR experiment helped me apply theoretical knowledge to practice, making me realize that biotechnology is not as tedious as I previously thought. Additionally, the mice experiments were a completely new experience. Some other instruments were quite complex and difficult to understand initially, but it was a unique experience. My target major has broadened, and I will consider more biology-related disciplines.
—— The Experimental School Affiliated with Zhuhai No. 1 High School, Student Shen
We were introduced to the background knowledge related to CAR-T on the first day, allowing us to understand the main work of the laboratory quickly. The clear flowcharts helped us promptly adapt to the environment and start the five-day course. The ten-hour experimental sessions provided us with ample hands-on experience. We learned how to use many new experimental instruments and understood their roles in experiments. The most memorable part was handling the mice and extracting T cells from tumors. This process was lengthy and complex, teaching me the techniques and importance of cherishing and respecting every experimental animal. XLAB was beneficial for my future professional choices, allowing meallowing me to explore my interests and passions.
—— A-level Center of Zhenhai High School of Zhejiang, Student Yu
This experiment significantly enhanced my understanding of various treatments, particularly in immunotherapy. I gained deeper insights into the effects and drawbacks of CAR-T cell modification, multiple methods, principles of adoptive immunotherapy, types of cancers suitable for adoptive immune cell therapy, and the methods and principles of different experiments. The most rewarding experiment for me was the observation and analysis of T cells in the tumors and spleens of mice and the comparison with control groups. This experiment expanded my knowledge of tumors and taught me a series of procedures for handling mice. Additionally, I learned some basics of flow cytometry data analysis. This experience served as a preview of the subjects I will study at university, greatly deepening my interest in the field.
—— Cambridge International Center, Beijing New Talent Academy, Student Xu