Development of a Biomimetic Cerebral Organ-on-Chip Platform for Studying Neuroprotective Mechanisms
Nanjing
Aug.1 - Aug.5
#Biomedical Engineering #Neuroscience #Cell Biology #Molecular Biology

Exploring the mysteries of the brain is one of the grandest challenges facing contemporary science. Brain science, as the "ultimate frontier" of life science research, not only pertains to human understanding of consciousness, memory, and emotion but also holds the key to overcoming numerous neurological diseases such as Alzheimer's disease and Parkinson's disease. Traditional animal models often have many limitations. Brain-on-a-chip technology, as a novel cutting-edge research tool, compensates for these shortcomings. Brain-on-a-chip technology, hailed as "recreating the life microenvironment in a petri dish", utilizes stem cell technology to cultivate 3D miniature brain tissue models on microfluidic chips, which can simulate part of the structure and function of the human brain, providing a new platform for simulating the real physiological and disease states of the brain. This project leads participants to use microfluidic technology to construct an in vitro "bionic human brain-on-a-chip," dynamically simulating the most critical biological barrier in the human brain from the blood-brain barrier to explore its working mechanism in protecting the brain and screening substances, helping them cultivate rigorous scientific thinking and solid experimental abilities

Teaching Faculty
Experts in Organs-on-chips from national research institutes are specially invited

Cutting-edge Topics
Systematically learn the key role and frontier applications of brain science and the blood-brain barrier in protecting the central nervous system

Real Lab Practice
Construct an in vitro “bionic human brain organ-on-a-chip” to simulate the blood-brain barrier, the most critical biological barrier in the human brain

Outcome Application
Research outcomes provide new scientific directions for tackling neurological diseases such as Alzheimer’s and Parkinson’s
Main Experiments

Microfluidic Chip Fabrication

Brain Organoids-on-Chip Model Construction Drug

Stimulation and Efficacy Evaluation

小鼠解剖实验

脑立体定位实验

动物焦虑行为实验
Certificates





项目感言
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在XLAB实验里,细胞培养实验让我收获最大。通过实操,我精准掌握了细胞复苏、传代、冻存等关键流程,明白严格把控无菌环境、消化时间对细胞状态的影响。这不仅提升了我的实验操作技能,更让我直观感受到生命科学研究的严谨性与魅力。我目标留学专业是生物医学,此次经历加深了我对专业研究内容的理解,坚定了我探索细胞机制、疾病治疗应用的决心,为未来专业学习筑牢实践根基,让我更清晰迈向留学后的专业研究之路 。—— 广州华美英语实验学校(国际高中部) 张同学

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在本次实验中,令我印象最深刻的是配置含有碳纳米材料富勒烯的雪花膏,了解到护肤品的常见组成部分及其功效上,我们掌握了乳化的原理与乳化的技术,让我深刻体会到了在不断努力并做出一系列成果之后的喜悦感与成就感。本人在大学专业有意向选择生物医学工程,本次项目的经历不仅让我掌握了纳米材料的处理,也让我认识到功能材料在改善日常产品性能方面的巨大潜力,坚定了我在生物医学专业领域深造的决心。—— 上海市民办平和学校(金鼎校区) 李同学

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细胞培养给我带来了很大的收获,提前进了实验室感受细胞培养及研究的过程,认识了这之前不认识的各种仪器,并上手进行了实操,我想比别人多了一份生物细胞培养的经验,并且阿思丹所能提供的证书对我以后的升学很有帮助,我以后想学的是有关生物医疗人工智能类的,我认为国外美本前30以及其他的像英国类的学校有很大的帮助英国类的学校很认可这个!—— 上海市民办万源城协和双语学校 李同学

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